Trauma is a health issue of epidemic proportions and accounts for the majority of deaths in people aged 1–44 years. Uncontrolled hemorrhage after injury is attributed to early death. Because of this, there is significant interest in understanding the postinjury spectrum of clotting dysfunction as a result of hypocoagulability or hypercoagulability. On presentation, one-third of severely injured and bleeding patients have acute traumatic coagulopathy with significant morbidity and a four-fold increase in mortality. ... read more